Arachne are enemies in Devil May Cry 3, and are first encountered during Mission 9: Faded Memories. They are the souls of human women that were transformed into monsters as they entered the netherworld. 
Arachne resemble giant spiders with blade-like forearms. They come in white or green varieties, with the green version having tougher carapaces in addition to a larger size. Both can shoot sticky webbing out of their mouths and spinnerets in order to ensnare their victims.
Like the Gigapede, Arachne are weak to fire, so Agni & Rudra are extra powerful against them. Arachne are very agile, able to crawl on the walls and jump around the Provisions Storeroom. Both types can give birth to weak infant Arachne if slain with a melee attack while reared back or knocked over. These little Arachne can be killed with one shot from the Ebony & Ivory, but if they crawl onto Dante they will eventually explode and inflict minor damage, making them only dangerous in large numbers.
Arachne was a renowned weaver in Greek mythology. Her skills were said to be greater than even those of the goddess Athena, and so the jealous goddess challenged her to a weaving duel. While Athena wove a scene glorifying the gods, Arachne wove a scene which not only depicted all of the gods' misdeeds, but was also considered the better tapestry. In a rage, Athena transformed Arachne into the first spider.
- The miniature spiders that often appear when an Arachne is killed are similar to the Phantom Babies from the first game.
- ↑ Devil May Cry 3: Dante's Awakening, Lesser Demons File — Arachne: "Once the soul of a human female, the soul transformed when it reached the outer crust of the netherworld. Uses her tightly spun spider webbing to ensnare her victims."
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