Secret Mission 05: One Eyed Evil
DMC Secret Mission 05
Lure the Kyklops into their mutal death.
Characters Dante
Location Mission 7 OR the interval between Mission 7 and Mission 8.
Demons Kyklops
Secret Mission Navigation
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"Secret Mission 4: Three Beasts" "Secret Mission 6: Wandering Ghosts"

To find this Secret Mission, you have to re-enter the room where you first encountered the Beelzebub. You can do this during Mission 7 or in the interval between Mission 7 or Mission 8, however; if you do the latter, it will not count towards your Devil Hunter Rank at the end of the mission. If done during Mission 7, your health will constantly decrease because of the Guiding Light you're holding.

To win this, you have to get one Kyklops to kill the other. Despite what the secret mission description says, you only need one Kyklops to kill the other: After that, you can polish off the second on your own. You can stand between them, jump when they attack, and hope that one eventually kills the other with their rock-spit attack. Another, safer way to do this is to jump onto the pipes jutting out of one side of the room, and let them blunder around until one dies. Then jump off and kill the second one.